Phagocytosis by Human Monocytes

Phagocytosis by human monocytes.

By MARm J. CLINE AND ROBERT I. LEminn T HE BLOOD MONOCYTES of mammals are phagocytic cells which are almost certainly related to the phagocytic tissue macrophages of the reticuloendothelial system. Morphologic and cytochemical studies mdicate that mononuclear cells isolated from the peripheral blood or peritoneal cavity of mammals can differentiate, under appropriate circumstances, into large c...

Phagocytosis by human eosinophils.

E OSINOPHILS were first recognized as a distinctive type of granulocyte over 100 years ago,’ and were observed to be capable of phagocytosis by Mesnil in 1895.2 Despite a voluminous literature on the morphology and functions of these cells, their precise role in normal man and in various diseases remains unclear. In general, eosinophils from higher mammals resemble other granulocytic cells in t...

Enhanced bacterial phagocytosis by peripheral blood monocytes in rheumatoid arthritis.

To assess the functional state of peripheral blood monocytes in rheumatoid arthritis, we have measured phagocytosis of Staphylococcus aureus and Proteus mirabilis in 48 patients and 28 controls. Using radiolabelled bacteria preopsonised in normal human serum we have demonstrated significantly enhanced uptake of both organisms by patients' monocytes: (Median % uptake Staph. aureus: patients = 35...

Interleukin-12 production by human monocytes infected with Mycobacterium tuberculosis: role of phagocytosis.

Mycobacterium tuberculosis and its antigens are potent inducers of cytokine expression by mononuclear phagocytes. In this study, the ability of live M. tuberculosis to stimulate interleukin-12 (IL-12) expression by human monocytes was examined. Monocytes were purified from peripheral blood mononuclear cells by adherence and either infected with M. tuberculosis or exposed to soluble protein anti...

Apoptotic Cells by Human Monocytes, and Cytokine Responses during Ingestion of C1q Differentially Modulates Phagocytosis